Bach2-deficient mice are prone to autoimmune pancreatitis but protected from high-fat diet-induced fatty liver disease
<i>Bach2</i>-deficient C57BL/6N mice were prone to spontaneous AIP development. This could be due to disturbed immune homeostasis with dysregulated activation of adaptive immune system cells. The protective effect of <i>Bach2</i> deficiency against the development of fatty liver disease warrants further investigation.
Authors
- Luise Ehlers (ORCID: https://orcid.org/0000-0001-8565-0560)
- Anika Kasprick (ORCID: https://orcid.org/0000-0003-0959-0900)
- Noa Linn Brauckmann
- Robert Jaster (ORCID: https://orcid.org/0000-0002-8220-4570)
- Ralf Joachim Ludwig (ORCID: https://orcid.org/0000-0002-1394-1737)
- Nicole Fischer (ORCID: https://orcid.org/0000-0001-7401-9271)
- Nancy Ernst (ORCID: https://orcid.org/0000-0002-3248-2425)
- Natalie Groß (ORCID: https://orcid.org/0000-0003-0773-3285)
- Colin Osterloh
- Katja Bieber (ORCID: https://orcid.org/0000-0002-3855-6683)
- Ottavia Agrifoglio (ORCID: https://orcid.org/0000-0002-3496-3097)
- Wendy Bergmann‐Ewert (ORCID: https://orcid.org/0000-0001-7221-3900)
- Alanis Barbosa Gulde
Institutions
- University of Rostock (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1639622
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00