Multiomics profiling reveals that P. gingivalis-induced extracellular vesicle reprogramming promotes immune evasion in colorectal cancer through autophagy-mediated STING degradation
This integrated multiomics analysis demonstrates that <i>P. gingivalis</i> infection profoundly remodels the molecular landscape of CRC cell-derived lEVs. The specific depletion of immune-stimulating factors, most notably STING, within lEVs suggests a novel mechanism by which this pathobiont may contribute to immune evasion and promote tumor progression in <i>P. gingivalis</i>-associated colorectal cancer.
Authors
- Lu Yang (ORCID: https://orcid.org/0000-0003-2532-8638)
- Fuping Wen (ORCID: https://orcid.org/0009-0005-3153-9820)
- Guangwei Shang
- Yiming Zhang (ORCID: https://orcid.org/0009-0001-0233-3541)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-9784-0481)
- Haixia Liu (ORCID: https://orcid.org/0000-0003-2189-2258)
- Yuanzhi Xu (ORCID: https://orcid.org/0009-0008-2943-2081)
- Jieying Huang
Institutions
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fcimb.2025.1604554
- Citations
- 3
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 2.39