Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds
Our new screening approaches identified novel inhibitors of GCPII that could serve as molecular templates for further structural optimization.
Authors
- Nate Hoxie (ORCID: https://orcid.org/0000-0001-5880-4165)
- Matthew Hall (ORCID: https://orcid.org/0000-0001-7018-7315)
- Takashi Tsukamoto (ORCID: https://orcid.org/0000-0002-0216-7520)
- Ying Wu (ORCID: https://orcid.org/0000-0002-6288-4636)
- Barbara Stauch Slusher (ORCID: https://orcid.org/0000-0001-9814-4157)
- Michael Ronzetti (ORCID: https://orcid.org/0000-0001-5034-7692)
- Stephen C. Kales (ORCID: https://orcid.org/0000-0002-8702-5766)
- John Janiszewski
- Ajit G. Thomas (ORCID: https://orcid.org/0000-0001-5922-5050)
- Jesse Alt (ORCID: https://orcid.org/0000-0001-5440-7891)
- Ganesha Rai (ORCID: https://orcid.org/0000-0001-9763-9641)
- Jonathan H. Shrimp (ORCID: https://orcid.org/0000-0001-9872-942X)
- Robyn Wiseman (ORCID: https://orcid.org/0000-0002-4537-0473)
- Rana Rais (ORCID: https://orcid.org/0000-0003-4059-2453)
- Ye Lin
- Xin Hu (ORCID: https://orcid.org/0000-0003-1164-5130)
- Chae Bin Lee (ORCID: https://orcid.org/0000-0003-4551-9191)
- Davina Adderley
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Center for Advancing Translational Sciences (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fphar.2025.1646207
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Center for Advancing Translational Sciences