Omega-3 fatty acid synergy with glucocorticoid in mouse lupus macrophage model: targeting pathogenic pathways to reduce steroid dependence
Altogether, DHA and DEX synergistically suppress inflammatory gene expression by targeting common and unique molecular pathways in SLE macrophages, favoring the pro-resolving M2 phenotype. O3FA-GC cotreatment might facilitate reducing requisite steroid dosages for SLE management.
Authors
- Rance Nault (ORCID: https://orcid.org/0000-0002-6822-4962)
- Andrew J. Olive (ORCID: https://orcid.org/0000-0003-3441-3113)
- Ashley N. Anderson (ORCID: https://orcid.org/0000-0002-7522-846X)
- J. Kasi Jackson (ORCID: https://orcid.org/0000-0002-1979-1426)
- James J. Pestka (ORCID: https://orcid.org/0000-0003-4689-2756)
- Lauren K. Heine
- J.R. Harkema
- Olivia F. McDonald (ORCID: https://orcid.org/0000-0001-9164-7077)
Institutions
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1646133
- Citations
- 1
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.11