Combined multi-omics approach to identify the key metabolites, key microorganisms and biomarkers correlated with the neutrophil extracellular traps-associated gene TIMP1 in osteoarthritis
TIMP1 acts as a pivotal regulator in OA, influencing inflammation, cartilage remodeling, metabolic pathways, and gut microbiota composition. This study provides novel mechanistic insights and potential therapeutic targets for OA.
Authors
- Xianguang Yang (ORCID: https://orcid.org/0000-0001-7241-1034)
- Jizheng Li
- Weiqing Ge (ORCID: https://orcid.org/0000-0001-5422-1325)
- Xi-Dan Hu (ORCID: https://orcid.org/0000-0003-3457-0872)
- Yaoyu Xiang (ORCID: https://orcid.org/0000-0003-3894-9548)
- Jing Yang (ORCID: https://orcid.org/0000-0001-6612-7854)
- Fei Sun (ORCID: https://orcid.org/0000-0003-4922-9706)
- Tao Zhou (ORCID: https://orcid.org/0000-0001-8508-9355)
- En Song
Institutions
- Kunming Medical University (CN)
- Dali Traditional Chinese Medicine Hospital (CN)
- Yunnan Provincial Hospital of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fphar.2025.1665228
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Yunnan Provincial Science and Technology Department