Quality assessment of “naturally occurring” high-percentage L-dopa commercial products proposed as dietary supplements on the Internet: from labeling to analytical findings
The obtained results showed evidence of potential risks related to consuming dietary supplements purchased online containing high-dose L-dopa. These risks arise from the inclusion of unauthorized botanical extracts, unclear labeling, and inconsistencies between labeled and actual dosages. Given the observed increasing public interest in levodopa, these findings highlight the need to control this market and inform consumers and physicians about the risks of purchasing unauthorized online products.
Authors
- Federica Aureli (ORCID: https://orcid.org/0000-0002-0601-5807)
- Domenico Di Giorgio (ORCID: https://orcid.org/0000-0002-9256-545X)
- Monica Bartolomei (ORCID: https://orcid.org/0000-0003-3569-4762)
- Marta Gramazio
- Alessandro Maccelli (ORCID: https://orcid.org/0000-0003-2725-1961)
- Mariangela Raimondo (ORCID: https://orcid.org/0000-0002-6766-7948)
- Anna Borioni (ORCID: https://orcid.org/0000-0003-4593-9460)
- Maria Cristina Gaudiano (ORCID: https://orcid.org/0000-0003-4236-7049)
Institutions
- Istituto Superiore di Sanità (IT)
- Italian Medicines Agency (IT)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fchem.2025.1597784
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Istituto Superiore di Sanità
- Agenzia Italiana del Farmaco, Ministero della Salute