miR-129 as a Molecular Biomarker in Gastric Cancer and Its Association with Neurodegenerative and Vascular Pathology
Gastric juice-derived miR-129 is downregulated in gastric adenocarcinoma, with progressive decline across tumor stages. Its inverse association with systemic tumor and inflammatory markers, as well as vascular and neurological impairment, suggests that miR-129 may function as a minimally invasive, multi-system biomarker for integrated cancer and vascular-neurological risk assessment.
Authors
- Roman Iulian
- Cristian Ichim (ORCID: https://orcid.org/0009-0005-9111-6088)
- Olga Brusnic
- Sabrina Bîrsan (ORCID: https://orcid.org/0009-0007-7368-7674)
- Blanca Grama
- Adrian Boicean (ORCID: https://orcid.org/0000-0002-6646-1585)
- Paula Anderco
- Tiberia Iliaș
- Samuel Bogdan Todor (ORCID: https://orcid.org/0000-0002-4283-0825)
- Corina Roman-Filip
- Anca-Rafila Stîngaciu (ORCID: https://orcid.org/0000-0002-0025-7864)
Institutions
- Lucian Blaga University of Sibiu (RO)
- University of Oradea (RO)
- Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș (RO)
Publication Details
- Journal
- Life
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3390/life15101603
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00