Identification of hub genes in congenital hypothyroidism and construction of the associated immune regulatory network
APP, DDB1, MRPS5, and MRPL33 regulate the expression of IL-2, act on relevant immune cell subtypes through the STAT5 and MTORC1 pathways, negatively regulate IL-18 and OPG, and positively regulate CD244, thereby influencing the activity of thyroid cells and the synthesis of FT4.
Authors
- Wenzhe Yang (ORCID: https://orcid.org/0009-0008-4085-0997)
- Mingliang Shan
- Shiguo Liu (ORCID: https://orcid.org/0000-0003-1911-9709)
- Li Xu
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Qingdao University (CN)
- Gaozhou People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1608098
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00