Systemic neutrophil activation and <i>N</i> ‐formyl methionine‐formyl peptide receptor‐1 signaling define inflammatory endotypes in rheumatoid arthritis‐associated lung involvement
The fMET-FPR1 axis is associated with neutrophil activation in RA-ILD and defines inflammatory endotypes associated with lung impairment. Neutrophil-based biomarkers may enable early risk stratification and provide rationale for targeting the fMET-FPR1 axis in RA-ILD.
Authors
- Joshua J. Solomon (ORCID: https://orcid.org/0000-0001-5488-4874)
- Ryan D. Stultz (ORCID: https://orcid.org/0000-0003-1859-9181)
- Xinping Tian (ORCID: https://orcid.org/0000-0002-1511-7952)
- M. Kristen Demoruelle (ORCID: https://orcid.org/0000-0002-2563-5155)
- Yiyun Pang (ORCID: https://orcid.org/0000-0002-4453-1626)
- Mengtao Li (ORCID: https://orcid.org/0000-0003-4252-2889)
- Christian Lood (ORCID: https://orcid.org/0000-0002-6171-1952)
- Xiaomin Liu (ORCID: https://orcid.org/0000-0003-2155-3627)
- Qian Wang (ORCID: https://orcid.org/0000-0002-4541-9898)
- Yu Chen (ORCID: https://orcid.org/0000-0003-3864-8446)
- Ting Wang (ORCID: https://orcid.org/0000-0002-8974-596X)
- Dan Ke
- Yang Wu (ORCID: https://orcid.org/0000-0002-0650-7713)
- Jia Shi (ORCID: https://orcid.org/0009-0001-3995-6697)
- Xueting Yuan
Institutions
- University of Denver (US)
- Ministry of Education of the People's Republic of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- University of Washington (US)
- Peking Union Medical College Hospital (CN)
- National Jewish Health (US)
- Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital (CN)
- Ministry of Education (KR)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1111/joim.70030
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Research Foundation
- China Scholarship Council
- Peking Union Medical College Hospital