The <scp>MMP</scp> ‐9/ <scp>TIMP</scp> ‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation
CSF MMP-9/TIMP-1 ratio and OPN are elevated in MS and decrease following aHSCT, reflecting reduced inflammation and restored BBB integrity. These biomarkers may support disease monitoring and therapeutic evaluation.
Authors
- Anna Wiberg (ORCID: https://orcid.org/0000-0002-4563-4432)
- Ida Erngren (ORCID: https://orcid.org/0000-0001-7867-9525)
- Malin Müller (ORCID: https://orcid.org/0000-0002-3385-6361)
- Kim Kultima (ORCID: https://orcid.org/0000-0002-0680-1410)
- Joachim Burman (ORCID: https://orcid.org/0000-0002-7045-1806)
- Ivan Pavlović (ORCID: https://orcid.org/0000-0002-7832-3083)
- Anders Olof Larsson (ORCID: https://orcid.org/0000-0003-3161-0402)
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Department of Medical Sciences (RU)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1002/acn3.70229
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Svenska Sällskapet för Medicinsk Forskning
- Vetenskapsrådet
- Svenska Läkaresällskapet
- Marcus och Amalia Wallenbergs minnesfond