Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Platelets, while essential for hemostasis, have been recognized as critical mediators in cancer metastasis. The crosstalk between platelets and circulating tumor cells (CTCs) constitutes a key driver of metastasis, emerging as a focal point in oncology research. Elucidating the underlying mechanisms provides novel insights into tumor dissemination. The present review systematically traces the evolution of platelet‑CTC crosstalk, from receptor‑mediated adhesion to bidirectional molecular exchange, and its implications for metastatic progression. Additionally, the diagnostic significance of platelet‑CTC complexes as potential biomarkers for cancer detection and prognosis is highlighted. Finally, promising therapeutic strategies targeting the platelet‑CTC crosstalk are discussed. By integrating current knowledge, it was demonstrated that targeting platelet‑CTC crosstalk holds potential for improving cancer diagnosis and therapy, while also identifying avenues for future translational research.