Virtual Screening of HBV Capsid Assembly Modulators with the Combination of Pharmacophore Modeling and Hydrogen Bond Constraints
Compounds B5, B19, and B21 can serve as promising starting points for the development of more potent anti-HBV candidates through future hit-to-lead optimization.
Authors
- Huihui Yan (ORCID: https://orcid.org/0000-0002-6978-6350)
- Yunwen Wang (ORCID: https://orcid.org/0000-0002-3197-1366)
- Rong Sheng (ORCID: https://orcid.org/0000-0002-5347-431X)
- Lei Xu (ORCID: https://orcid.org/0000-0002-4095-6539)
- Yanzhen Yu
- Hui Zhao (ORCID: https://orcid.org/0000-0002-1693-0128)
Institutions
- Jiangsu University of Technology (CN)
- Zhejiang Pharmaceutical College (CN)
- Zhejiang University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-10-08
- DOI
- https://doi.org/10.2174/0115734064409397250925105306
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00