Allostatic load in major depressive disorder: An in-patient clinical study
These findings suggest that AL reflects underlying multisystem dysregulation in MDD rather than symptom severity or treatment responsiveness. The observed decrease in AL during treatment may indicate an effect of antidepressants, although further research with longer follow-up is needed. The observed potential sex difference in AL warrants further investigation using larger sample sets.
Authors
- Sabine Westphal (ORCID: https://orcid.org/0000-0002-5846-3345)
- Johann Steiner (ORCID: https://orcid.org/0000-0002-2611-2268)
- Paul C. Guest (ORCID: https://orcid.org/0000-0002-5030-7137)
- Sabine Bahn (ORCID: https://orcid.org/0000-0003-4690-6302)
- Beena Suvarna (ORCID: https://orcid.org/0000-0001-6356-6456)
- Gabriela Meyer-Lotz (ORCID: https://orcid.org/0000-0002-9555-879X)
- Sabine Finlay (ORCID: https://orcid.org/0009-0004-6590-6943)
- Henrik Dobrowolny (ORCID: https://orcid.org/0000-0003-3393-3037)
- Donna Rudd (ORCID: https://orcid.org/0000-0002-4895-1791)
- Zóltan Sarnyai (ORCID: https://orcid.org/0000-0002-2380-7902)
- Brett McDermott (ORCID: https://orcid.org/0000-0002-6639-1767)
- Oyelola A. Adegboye (ORCID: https://orcid.org/0000-0002-9793-8024)
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of Cambridge (GB)
- Australian Institute of Tropical Health and Medicine (AU)
- Charles Darwin University (AU)
- Tasmanian Abalone Council (Australia) (AU)
- University Hospital Magdeburg (DE)
- James Cook University (AU)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Psychoneuroendocrinology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.psyneuen.2025.107653
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00