Radical-induced lipid oxidation produces a torrent of leukotriene-like agonists in severe asthma
Urinary øLTs are new biomarkers that may facilitate noninvasive assessment of asthma severity and the efficacy of therapeutic measures. Presumably øLTs contribute to CysLT receptor-mediated inflammation through CysLT-like inflammatory biological activities previously ascribed uniquely to CysLTs. øLTs provide a mechanistic link between radical-induced biochemistry, activation of the extracellular signal-regulated kinase/Akt pathway, and asthma. These discoveries require re-examination of long-held disease paradigms for the involvement of CysLTs in asthma pathology and reconsideration of the mechanistic basis for the efficacy of CysLT receptor antagonists for ameliorating chronic asthma. Inhibiting the biosynthesis of øLTs may provide new therapeutic strategies for preventing asthmatic inflammation.
Authors
- Masaru Miyagi (ORCID: https://orcid.org/0000-0003-4325-1216)
- Sailaja Paruchuri (ORCID: https://orcid.org/0000-0003-2377-4327)
- Fariba Rezaee (ORCID: https://orcid.org/0000-0002-7625-3341)
- Shuai Zhu (ORCID: https://orcid.org/0000-0001-7657-1078)
- Mikhail Linetsky
- Lakshminarayan Reddy Teegala (ORCID: https://orcid.org/0000-0001-7725-8294)
- Robert G. Salomon (ORCID: https://orcid.org/0000-0001-9456-3557)
- Kaixi Cui
- Yu-Shiuan Cheng (ORCID: https://orcid.org/0000-0002-7408-7888)
- Olivia T. Laniak (ORCID: https://orcid.org/0009-0001-0620-8983)
- Abby M. Hite
- Si‐Yang Liu (ORCID: https://orcid.org/0000-0002-5105-6421)
- Siqi Huang (ORCID: https://orcid.org/0000-0002-4272-5670)
- Hong Zeng (ORCID: https://orcid.org/0000-0002-5781-8773)
- A. Meneses
- Mingkuan Qin
- Emma Sintic
- Carolyn M Koutures
Institutions
- Cleveland Clinic Lerner College of Medicine (US)
- Case Western Reserve University (US)
- University of Toledo (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.jaci.2025.09.027
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16