Multi-Method Investigation of Icariin's Effects on Diabetic Cognitive Impairment: From Network Prediction to Experimental Confirmation
ICA protects HT22 cells from high glucose-induced damage via MAPK signaling and reduces inflammation, suggesting therapeutic potential for diabetic cognitive impairment. Further in vivo validation is warranted.
Authors
- Wen-Tao Yao
- Bin Yan (ORCID: https://orcid.org/0000-0001-5607-3012)
- Junxiong Zhou (ORCID: https://orcid.org/0000-0001-7455-0759)
- Dan‐Yang Wang (ORCID: https://orcid.org/0000-0001-8735-0422)
- Xinyi Jiao (ORCID: https://orcid.org/0000-0001-5618-8223)
- Guoqing Tian (ORCID: https://orcid.org/0000-0003-1262-2723)
- Yue Hu (ORCID: https://orcid.org/0000-0003-4759-1998)
- Xudong Liu (ORCID: https://orcid.org/0000-0002-7269-1803)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- CNS & Neurological Disorders - Drug Targets
- Published
- 2025-10-07
- DOI
- https://doi.org/10.2174/0118715273406743250831224035
- Citations
- 1
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 1.56