GOLM1-induced Vascular Permeability and Angiogenesis in Hepatocellular Carcinoma through Modulation of Cancer Cell-derived Exosomal microRNAs
Our findings suggest that, under the control of GOLM1, HCC cell-derived exosomal miR-4449 and miR-3651 increase angiogenesis and vascular permeability by targeting KEAP1 and ZO-1, highlighting the potential of exosomal miRNAs as promising therapeutic targets for HCC.
Authors
- Chong Huang (ORCID: https://orcid.org/0000-0001-7057-9992)
- Jubo Zhang (ORCID: https://orcid.org/0000-0003-2954-9403)
- Meisi Huo (ORCID: https://orcid.org/0000-0003-4912-2247)
- Fujing Cai
- Ruiqi Yin
- Kangkang Yu (ORCID: https://orcid.org/0000-0003-3509-0977)
- Yahui Zheng
- Jiguang Ding
Institutions
- Fudan University (CN)
- Wenzhou Medical University (CN)
- Ruian People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-10-08
- DOI
- https://doi.org/10.2174/0115680096391348250916080657
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00