Side Chain Effects on the Lipophilicity-antimicrobial-toxicity Correlation of Greener 4-Alkoxy/Amino-7-Chloroquinolines
Considering the results for compounds 1-3 and 6-8 with greater activity against C. albicans and P. aeruginosa, respectively, especially for 4-amino-7-chloroquinolines 6 and 7, which are slightly toxic on A. salina larvae (LC50 500-1000 μg mL-1), their antimicrobial studies deserve to be continued by the determination of Minimum Inhibitory Concentration (MIC) values.
Authors
- Gabriela F. Fiss (ORCID: https://orcid.org/0000-0001-8156-2272)
- Everton P. Silva
- Helivaldo Diógenes da Silva Souza (ORCID: https://orcid.org/0000-0002-1708-4066)
- Maria Helena do Nascimento (ORCID: https://orcid.org/0000-0002-8385-6810)
- Petrônio Filgueiras de Athayde Filho (ORCID: https://orcid.org/0000-0003-0982-8261)
- Krystyna Gorlach‐Lira (ORCID: https://orcid.org/0000-0002-7892-2705)
- Rádamis Barbosa Castor (ORCID: https://orcid.org/0000-0001-6665-8786)
- Abraão P. Sousa (ORCID: https://orcid.org/0009-0005-6585-2866)
- Marta Suely Madruga (ORCID: https://orcid.org/0000-0002-7518-0742)
Institutions
- Universidade Federal da Paraíba (BR)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-10-15
- DOI
- https://doi.org/10.2174/0109298673372039250614231629
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00