Prolongation of peripheral nerve block by Marmara Propolis: an experimental rat study

Marmara propolis, particularly when used in combination with bupivacaine, prolongs sensory, deep sensory, and motor block durations. These findings suggest that propolis may have both local and systemic adjuvant effects in regional anaesthesia applications.HIGHLIGHTS OF THE STUDYMarmara propolis significantly prolonged sensory, deep sensory, and motor block durations when administered perineurally in a rat sciatic nerve block model.Intraperitoneal administration of propolis also resulted in prolonged deep sensory and motor block recovery, indicating systemic analgesic activity.The combination of bupivacaine and propolis produced the longest block durations, suggesting a synergistic or adjuvant effect.This is the first study to investigate both local and systemic applications of propolis as an adjunct to regional anaesthesia.Findings support the potential use of propolis as a natural, plant-based adjuvant in peripheral nerve blocks.