Differential fracture risk in breast cancer patients based on endocrine therapy and age: a nationwide cohort study
Among breast cancer patients aged over 50 years, AI use was not associated with increased risk of compared to non-users. Tamoxifen use was linked to reduced risk of fracture, but not in patients under 50. Considering the relatively young age of breast cancer diagnosis in Korea, long-term follow-up studies are warranted. After adjusting for confounders including age, among breast cancer patients aged over 50 years, AI use was not associated with increased risk of fracture compared to non-users. Tamoxifen use was linked to reduced risk of fracture, but not in patients under 50.
Authors
- Jean Kyung Bak (ORCID: https://orcid.org/0000-0002-8763-5580)
- Jung-Wee Park (ORCID: https://orcid.org/0000-0002-4515-1895)
- You Jin Lee (ORCID: https://orcid.org/0000-0002-1224-0875)
- Young‐Kyun Lee (ORCID: https://orcid.org/0000-0001-6564-4294)
- Ye Jin Jeon (ORCID: https://orcid.org/0000-0002-3780-5668)
- Bit‐Na Yoo (ORCID: https://orcid.org/0000-0001-6217-6798)
- Jinyoung Lee (ORCID: https://orcid.org/0000-0002-7313-5227)
- Ha Young Kim (ORCID: https://orcid.org/0000-0002-0651-2213)
- Mi Kyung Kwak (ORCID: https://orcid.org/0000-0002-8092-2560)
Institutions
- Seoul National University (KR)
- Yonsei University (KR)
- Seoul National University Bundang Hospital (KR)
- National Cancer Center (KR)
- National University College (PR)
- Gangneung Asan Hospital (KR)
- National Evidenc- based healthcare Collaborating Agency (KR)
- Hallym University Dongtan Sacred Heart Hospital (KR)
- Chung-Ang University (KR)
Publication Details
- Journal
- Osteoporosis International
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1007/s00198-025-07639-2
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Seoul National University
- National Evidence-based Healthcare Collaborating Agency
- Korea Health Industry Development Institute