Development of Patient-Derived Conditionally Reprogrammed 3D Breast Cancer Culture Models for Drug Sensitivity Evaluation
Patient-derived 3D CRBC models effectively mimic the <i>in vivo</i> tumor microenvironment and demonstrate stronger resistance to anti-cancer drugs than 2D models. These hydrogel-based models offer a cost-effective and clinically relevant platform for drug screening and personalized breast cancer treatment.
Authors
- Weiling Guo
- Wen Zhou (ORCID: https://orcid.org/0000-0003-0628-6444)
- Zhong Zhen Guan (ORCID: https://orcid.org/0000-0003-4808-7400)
- Ting Huang (ORCID: https://orcid.org/0000-0001-8751-639X)
- Pangzhou Chen
- Jing Cai (ORCID: https://orcid.org/0000-0001-8002-2645)
- Huijuan Zhu (ORCID: https://orcid.org/0000-0002-8045-6539)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-10-15
- DOI
- https://doi.org/10.32604/or.2025.069902
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00