Therapeutic effects of Poncirus fructus on colonic dysfunction and visceral pain in a zymosan-induced irritable bowel syndrome mouse model through interstitial cells of Cajal and ion channel modulation
PFE exerts multi-target effects by modulating ICC activity, suppressing inflammation, and regulating key ion channels involved in visceral pain. These findings suggest that PFE has therapeutic potential for the management of IBS symptoms.
Authors
- Woo-Gyun Choi (ORCID: https://orcid.org/0000-0003-4689-6394)
- Jae‐Woo Park
- Na Ri Choi
- Dong Wook Lim (ORCID: https://orcid.org/0000-0002-2386-8414)
- Byung Joo Kim (ORCID: https://orcid.org/0000-0001-8835-9103)
- Seok‐Jae Ko (ORCID: https://orcid.org/0000-0002-9902-0938)
- Yun Tai Kim (ORCID: https://orcid.org/0000-0002-3404-6977)
- Dae-Hwa Jung
- Sang Chan Kim (ORCID: https://orcid.org/0000-0003-0515-0764)
- Joohan Woo (ORCID: https://orcid.org/0000-0001-5152-8057)
Institutions
- Daegu Haany University (KR)
- Dongguk University (KR)
- Kyung Hee University (KR)
- Korea Food Research Institute (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- Pusan National University (KR)
- Korea University of Science and Technology (KR)
- Daegu University (KR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fphar.2025.1639592
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Korea Food Research Institute