Vascular Niches Are the Primary Hotspots in Cardiac Aging
Our findings indicate that the perivascular microenvironment is particularly susceptible to age-related changes and serves as a primary site for inflammation-driven aging, so-called inflammaging. This study provides new insights into how aging reshapes cardiac cellular architecture, highlighting vessel-associated niches as potential therapeutic targets for age-related cardiac dysfunction.
Authors
- David John (ORCID: https://orcid.org/0000-0003-3217-5449)
- Denada Arifaj (ORCID: https://orcid.org/0009-0004-2759-6999)
- Stefanie Dimmeler (ORCID: https://orcid.org/0000-0002-1045-2436)
- Julian U. G. Wagner (ORCID: https://orcid.org/0000-0002-3863-854X)
- Veronica Larcher (ORCID: https://orcid.org/0000-0002-4398-7058)
- Andreas M. Zeiher (ORCID: https://orcid.org/0000-0003-1711-5819)
- Lukas Zanders (ORCID: https://orcid.org/0000-0003-0488-6243)
- David Rodríguez Morales (ORCID: https://orcid.org/0000-0002-1819-6991)
- Christoph Kuppe (ORCID: https://orcid.org/0000-0003-4597-9833)
- Mariano Ruz Jurado (ORCID: https://orcid.org/0000-0001-5354-5336)
- Marcel H. Schulz (ORCID: https://orcid.org/0000-0002-1252-3656)
- Lukas Tombor (ORCID: https://orcid.org/0000-0002-5867-576X)
Institutions
- Goethe University Frankfurt (DE)
- German Centre for Higher Education Research and Science Studies (DE)
- University Hospital Frankfurt (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1161/circresaha.125.327060
- Citations
- 6
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 4.84