The β <sub>IV</sub> -Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth
These data identify a novel and pivotal role for β<sub>IV</sub>-spectrin/STAT3 to modify microtubule properties and sarcomeric transcript distribution to direct myocyte geometry in response to chronic stress. These studies further illustrate the unique separation of hypertrophic growth and orientation as distinct pathways in cardiac remodeling.
Authors
- Jennifer M. Pyles (ORCID: https://orcid.org/0000-0001-9049-4275)
- Alexander J. Winkle (ORCID: https://orcid.org/0000-0003-1226-2449)
- Thomas J. Hund (ORCID: https://orcid.org/0000-0002-9957-7306)
- Omer Cavus (ORCID: https://orcid.org/0000-0002-2930-3975)
- Haiyan Liu (ORCID: https://orcid.org/0000-0002-4652-469X)
- Simon Lococo (ORCID: https://orcid.org/0009-0001-9982-053X)
- Shivangi Mohta (ORCID: https://orcid.org/0000-0003-2040-9471)
- Nicholas Leahy (ORCID: https://orcid.org/0000-0002-4784-6228)
- Drew Nassal (ORCID: https://orcid.org/0000-0002-8018-3913)
- Xianyao Xu (ORCID: https://orcid.org/0000-0001-7834-4880)
- Rebecca Shaheen (ORCID: https://orcid.org/0000-0002-5121-8558)
- Benjamin Buck (ORCID: https://orcid.org/0000-0002-6065-3885)
Institutions
- The Ohio State University Wexner Medical Center (US)
- Lung Institute (US)
- The Ohio State University (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1161/circresaha.125.326378
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00