High Rate Triggers Increased Atrial Release of BMP10, A Biomarker for Atrial Fibrillation and Stroke, and BMP10 Affects Ventricular Cardiomyocytes
High atrial rates elevate BMP10 expression and release, and higher plasma concentrations of BMP10 are observed in patients with active AF. BMP10 exposure induces transcriptomic changes linked to AF and heart failure in ventricular EHT. These findings support BMP10 as a biomarker and potential mediator of AF-related remodeling and tachycardiomyopathy.
Authors
- Justus Stenzig
- Ryan T. Gardner
- Julius Ridder (ORCID: https://orcid.org/0009-0005-7061-8441)
- Thomas Eschenhagen (ORCID: https://orcid.org/0000-0003-1750-1170)
- Bangfen Pan
- Paulina Sander (ORCID: https://orcid.org/0000-0002-2384-3954)
- Tanja Zeller (ORCID: https://orcid.org/0000-0003-3379-2641)
- Paulus Kirchhof (ORCID: https://orcid.org/0000-0002-1881-0197)
- Laura C. Sommerfeld (ORCID: https://orcid.org/0000-0001-9837-8770)
- Bente Siebels (ORCID: https://orcid.org/0000-0001-9183-0381)
- Christopher O’Shea (ORCID: https://orcid.org/0000-0003-3030-7364)
- Laura Bravo-Merodio (ORCID: https://orcid.org/0000-0001-8878-8434)
- Larissa Fabritz (ORCID: https://orcid.org/0000-0002-9241-1733)
- Hartwig Wieboldt
- Nathan R. Tucker (ORCID: https://orcid.org/0000-0002-5071-4218)
- Karl-Felix Müller
- Grit Höppner
- Winnie Chua (ORCID: https://orcid.org/0000-0002-6747-8813)
- Marc N. Hirt (ORCID: https://orcid.org/0000-0003-4728-965X)
- Yanish Purmah
- Jessica Schrapers
- A. M. Stella Vermeer-Stoter
Institutions
- Universität Hamburg (DE)
- SUNY Upstate Medical University (US)
- Sandwell & West Birmingham Hospitals NHS Trust (GB)
- University of Warwick (GB)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- Heart Foundation (US)
- University Medical Center Hamburg-Eppendorf (DE)
- German Centre for Cardiovascular Research (DE)
- Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
- Cancer Research UK Clinical Trials Unit (GB)
- Center for Genomic Science (IT)
- Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (FR)
- University of Birmingham (GB)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1161/circep.125.013834
- Citations
- 1
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 2.01