Feminizing Adrenocortical Carcinoma in Men: A Rare Cause of Persistent Gynecomastia and a Contemporary Literature Review
This case illustrates the rare presentation of feminizing adrenocortical carcinoma with reversible infertility and highlights the importance of early recognition and close surveillance. In addition, our literature review of 12 male cases reported between 2015 and 2025 emphasizes gynecomastia as the hallmark presentation and discusses emerging evidence supporting active surveillance as a potential alternative to adjuvant mitotane in selected low-risk patients.
Authors
- Mariana Costea (ORCID: https://orcid.org/0000-0003-4924-739X)
- C. Gîngu (ORCID: https://orcid.org/0000-0002-4000-0430)
- Victor Nimigean (ORCID: https://orcid.org/0000-0002-6056-3214)
- C Neamţu
- Bogdan Grecu
- Sorin Păun (ORCID: https://orcid.org/0009-0007-8301-4131)
- Alina Onofrei
- Diana Loreta Păun
- Dana-Mihaela Tilici (ORCID: https://orcid.org/0009-0001-5655-2694)
- Ana Maria Arnautu
- Claudia Nacea-Radu
- Ruxandra Costinescu
Institutions
- Carol Davila University of Medicine and Pharmacy (RO)
- Clinical Emergency Hospital Bucharest (RO)
- Emergency University (US)
- Institutul Clinic Fundeni (RO)
Publication Details
- Journal
- Epidemiologia
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3390/epidemiologia6040064
- Citations
- 1
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 2.01