Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation
Mitochondrial Ca<sup>2+</sup> uptake and accumulation are impaired in atrial myocytes from patients with AF. The disturbed spatial association between sarcoplasmic reticulum and mitochondria driven by destabilized microtubules may underlie impaired Ca<sup>2+</sup> transfer in AF. Enhancing mitochondrial Ca<sup>2+</sup> uptake potentially protects against arrhythmogenic events.
Authors
- A.F. Jebran (ORCID: https://orcid.org/0000-0003-4281-0960)
- C. Bening (ORCID: https://orcid.org/0000-0003-3120-9125)
- Constanze Schmidt (ORCID: https://orcid.org/0000-0001-8702-4977)
- Ivan Bogeski (ORCID: https://orcid.org/0000-0001-9879-7174)
- Julius Ryan D. Pronto (ORCID: https://orcid.org/0000-0003-3556-5637)
- Katharina Ritzenhoff
- Felix Bremmer (ORCID: https://orcid.org/0000-0003-0367-6527)
- Ingo Kutschka (ORCID: https://orcid.org/0000-0002-7358-3513)
- Sören Brandenburg (ORCID: https://orcid.org/0000-0001-5148-0997)
- Funsho E. Fakuade (ORCID: https://orcid.org/0000-0001-6683-6079)
- Stephan E. Lehnart (ORCID: https://orcid.org/0000-0002-8115-3513)
- Niels Voigt (ORCID: https://orcid.org/0000-0001-8230-2341)
- Johann Schredelseker (ORCID: https://orcid.org/0000-0002-6657-0466)
- Fleur E. Mason (ORCID: https://orcid.org/0009-0001-6583-0190)
- Bianca J.J.M. Brundel (ORCID: https://orcid.org/0000-0002-4768-234X)
- Aschraf El‐Essawi (ORCID: https://orcid.org/0000-0002-5583-039X)
- Stefanie Kestel
- Michael Kohlhaas (ORCID: https://orcid.org/0000-0001-6132-6037)
- Christoph Maack (ORCID: https://orcid.org/0000-0003-3694-4559)
- Stefan M. Kallenberger (ORCID: https://orcid.org/0000-0003-3783-0246)
- Stefan Neef (ORCID: https://orcid.org/0000-0001-5116-3924)
- Silvio O. Rizzoli (ORCID: https://orcid.org/0000-0002-1667-7839)
- Björn C. Knollmann (ORCID: https://orcid.org/0000-0003-4956-9735)
- Julian Mustroph (ORCID: https://orcid.org/0000-0001-9668-7852)
- Eva A. Rog‐Zielinska (ORCID: https://orcid.org/0000-0002-3295-4728)
- Katrin Streckfuß‐Bömeke (ORCID: https://orcid.org/0000-0001-5137-7228)
- George Kensah (ORCID: https://orcid.org/0000-0003-0219-8279)
- Felix Wiedmann (ORCID: https://orcid.org/0000-0001-8168-0025)
- Tri Q. (ORCID: https://orcid.org/0009-0007-8370-2823)
- Xiaobo Zhou (ORCID: https://orcid.org/0000-0002-5895-0127)
- Robyn T. Rebbeck (ORCID: https://orcid.org/0000-0003-3840-2286)
- Hassina Baraki (ORCID: https://orcid.org/0000-0003-3938-6484)
- Alexander Nickel (ORCID: https://orcid.org/0000-0002-7761-0769)
- Matthias Wolf
- Bernhard C. Danner
- MJ Toth
- K.C. Tran Vu
- Zongqian Xue
- Khaled Machwart
- Oksana Kyshynska
- Paulina Brandes
- Peter Joshua Siedler
- Olga Dschun
- Donata Bülow
Institutions
- University of Minnesota (US)
- University of Freiburg (DE)
- Justus-Liebig-Universität Gießen (DE)
- Heidelberg University (DE)
- University of Würzburg (DE)
- University Hospital Heidelberg (DE)
- University Hospital Regensburg (DE)
- Comprehensive Cancer Center Mainfranken (DE)
- National Center for Tumor Diseases (DE)
- Universitätsmedizin Göttingen (DE)
- Universitätsklinikum Würzburg (DE)
- German Centre for Cardiovascular Research (DE)
- Norwegian Womens Public Health Association (NO)
- Institute of Molecular Biology and Biophysics (RU)
- University Medical Centre Mannheim (DE)
- Institute of Pharmacology (CZ)
- Czech Academy of Sciences, Institute of Physiology (CZ)
- University of Regensburg (DE)
- University of Göttingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Vrije Universiteit Amsterdam (NL)
- Vanderbilt University Medical Center (US)
- Praxis (EE)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1161/circresaha.124.325658
- Citations
- 5
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- Florida Education Fund
- Vanderbilt University
- University of Minnesota
- Deutsches Zentrum für Herz-Kreislaufforschung
- Vanderbilt University Medical Center
- Universitätsmedizin Göttingen
- Amsterdam University Medical Centers
- Deutsche Forschungsgemeinschaft
- Universität Heidelberg
- Albert-Ludwigs-Universität Freiburg
- Else Kröner-Fresenius-Stiftung
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Universitätsklinikum Regensburg
- Universität Regensburg
- Ludwig-Maximilians-Universität München
- Deutsche Herzstiftung
- Julius-Maximilians-Universität Würzburg
- Universitätsklinikum Heidelberg
- National Institutes of Health
- Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers
- Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg
- National Center for Advancing Translational Sciences
- Common Fund