The establishment of a universal standard for both viral antigen and nucleid acid detection based on digital PCR
We established and validated a BPL-inactivated universal national standard specifically designed to overcome the difficulties in quantifying antigen and enabling direct sensitivity comparison between SARS-CoV-2 Ag-RDTs and NAATs.
Authors
- Xun Cheng
- Tingting Ma (ORCID: https://orcid.org/0000-0003-1236-1543)
- Siyuan Yang (ORCID: https://orcid.org/0000-0002-2636-9610)
- Donglai Liu (ORCID: https://orcid.org/0000-0002-9849-5683)
- Yong Guo (ORCID: https://orcid.org/0000-0003-3175-3008)
- Alimire Abulikemu
- Jing Li (ORCID: https://orcid.org/0000-0001-9392-6600)
- Pengfei Wang (ORCID: https://orcid.org/0009-0002-2900-5561)
- Chunlei Zhang (ORCID: https://orcid.org/0000-0002-0939-2149)
- Haiwei Zhou (ORCID: https://orcid.org/0000-0003-1352-6581)
- Manyu Li (ORCID: https://orcid.org/0000-0002-8679-1346)
- Jia Lu (ORCID: https://orcid.org/0000-0001-5084-818X)
- Linghang Wang (ORCID: https://orcid.org/0000-0002-1948-5461)
Institutions
- China Banking Regulatory Commission (CN)
- Sinovac Biotech (CN)
- Wuhan Institute of Bioengineering (CN)
- National Institutes for Food and Drug Control (CN)
- Bio-Medical Science (South Korea) (KR)
- Beijing Ditan Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12985-025-02954-w
- Citations
- 2
- Primary Topic
- SARS-CoV-2 detection and testing
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Key Research and Development Program of China