Nuclear receptor Nr1d1 links sleep deprivation to intestinal homeostasis via microbiota-derived taurine
Together, these findings reveal a gut microbiota-taurine-Nr1d1 axis underlying sleep deprivation-induced intestinal barrier dysfunction, and suggest that therapeutic modulation of taurine levels or circadian pathways may offer novel strategies to prevent or treat sleep-related gastrointestinal disorders.
Authors
- Xiaolan Zhong (ORCID: https://orcid.org/0000-0003-4819-0416)
- Rufei Huang (ORCID: https://orcid.org/0000-0002-8440-0890)
- Wei Sun (ORCID: https://orcid.org/0000-0002-7366-1462)
- Wanglin Li (ORCID: https://orcid.org/0000-0002-2103-0271)
- Shuai Wang (ORCID: https://orcid.org/0000-0002-8895-5199)
- Lili Zhou (ORCID: https://orcid.org/0000-0001-5044-6965)
- Zhaoyang Wang (ORCID: https://orcid.org/0000-0003-0678-0346)
- Yaxin Zheng (ORCID: https://orcid.org/0000-0002-0963-9025)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- New Huadu Business School (CN)
- 421 Hospital of PLA (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12967-025-07089-8
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42