FAM19A4 and miR124-2 methylation status in human papillomavirus-driven and human papillomavirus-negative oropharyngeal squamous cell carcinomas
Our findings indicate that FAM19A4/miR124-2 hypermethylation occurs exclusively in tumor samples and that methylation levels are significantly higher in HPV-driven OPCs than in HPV-negative OPCs.
Authors
- Francesca Rollo (ORCID: https://orcid.org/0000-0003-2724-872X)
- Alessandra Latini (ORCID: https://orcid.org/0000-0002-9421-6560)
- Silvia Moretto (ORCID: https://orcid.org/0000-0003-2776-4433)
- Eugenia Giuliani (ORCID: https://orcid.org/0000-0002-9721-4173)
- Raul Pellini (ORCID: https://orcid.org/0000-0001-6051-3041)
- Maria Gabriella Donà (ORCID: https://orcid.org/0000-0003-3250-1726)
- Renato Covello (ORCID: https://orcid.org/0000-0001-8505-4427)
- Valentina Laquintana (ORCID: https://orcid.org/0000-0002-7374-5279)
- Maria Benevolo (ORCID: https://orcid.org/0000-0003-1994-0935)
Institutions
- National Cancer Institute (MY)
- San Gallicano Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Infectious Agents and Cancer
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s13027-025-00697-5
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute