Evidence of neurocognitive and resting state functional connectivity differences in carriers of NRXN1 deletions
This exploratory study provides evidence for neurocognitive impacts and brain functional differences related to underlying synaptic mechanisms. Brain functional differences in NRXN1 del carriers may support altered excitation/inhibition dynamics within the brain. Gene-first approaches may establish brain-based translational markers to identify neurobiologically informed subgroups within neurodevelopmental and neuropsychiatric conditions, and ultimately transdiagnostic therapeutic strategies.
Authors
- Richard B. Reilly (ORCID: https://orcid.org/0000-0001-8578-1245)
- Jacqueline Fitzgerald (ORCID: https://orcid.org/0000-0001-6553-4378)
- Elizabeth A. Heron (ORCID: https://orcid.org/0000-0003-2219-4005)
- Matthew L. O’Sullivan (ORCID: https://orcid.org/0000-0003-2201-0106)
- Niamh Feerick
- Thomas Dinneen (ORCID: https://orcid.org/0000-0003-3767-6859)
- Sanbing Shen (ORCID: https://orcid.org/0000-0002-8217-9811)
- Clare Kelly (ORCID: https://orcid.org/0000-0001-8253-357X)
- Louise Gallagher (ORCID: https://orcid.org/0000-0001-9462-2836)
- Ciara J. Molloy (ORCID: https://orcid.org/0000-0002-6178-8861)
- Sally Ann Lynch (ORCID: https://orcid.org/0000-0003-3540-1333)
- Maryam Al-Shehhi
- Richard O’Conaill
Institutions
- University College Dublin (IE)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Trinity College Dublin (IE)
- Hospital for Sick Children (CA)
- Shaikh Khalifa Medical City (AE)
- Children's Health Ireland at Crumlin (IE)
- Temple Street Children's University Hospital (IE)
- Ontario Centre of Excellence for Child and Youth Mental Health (CA)
- SickKids Foundation (CA)
Publication Details
- Journal
- Journal of Neurodevelopmental Disorders
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s11689-025-09625-5
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Trinity College Dublin