Association of vitamin D receptor mRNA expression, vitamin D deficiency and genetic variant in patients with multi-drug resistant pulmonary tuberculosis

In present study, the VDR gene's FokI polymorphism affects the levels of VDR mRNA expression, with the ff genotype linked to lower expression in both MDR-TB patients and healthy individuals. Nonetheless, there were no appreciable differences in the genotypic and allelic frequencies of FokI between the groups. These findings suggest that the location of the FokI variation in the population may not be as important to MDR-TB susceptibility as its functional impact on gene expression.