FAIM modulates HCC progression via enhancing HMGA1 interaction with CDK7 and promoting its phosphorylation level
Summarily, we elucidated that FAIM modulated HCC progression through facilitating the interaction of CDK7 and HMGA1 as well as elevating HMGA1 phosphorylation and stability.
Authors
- Suofeng Sun (ORCID: https://orcid.org/0000-0002-5604-3371)
- Wenna Liu
- Mingbo Cao (ORCID: https://orcid.org/0000-0001-7830-4686)
- Xingjun Fan (ORCID: https://orcid.org/0000-0002-6477-4465)
- Yuan Li (ORCID: https://orcid.org/0000-0002-7895-2525)
- Xiuling Li
- Xinyi Wu (ORCID: https://orcid.org/0009-0005-2297-2622)
- Amin Wurita
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- Henan Provincial People's Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12967-025-07148-0
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00