Longitudinal multi-omics analyses of chemotherapy-induced peripheral neuropathy in response to taxanes
Our study offers valuable insights into the molecular mechanisms of CIPN in breast cancer patients treated with taxanes. By identifying key molecular markers and pathways, such as CREB and opioid signaling, we provide initial evidence for hypothesis generation and future research. While these findings are correlative and require further validation, they highlight potential biological mechanisms and serve as a basis for validating candidates as biomarkers or therapeutic targets.
Authors
- Courtney E. Hershberger (ORCID: https://orcid.org/0000-0002-2195-989X)
- Anukriti Sharma
- Jennifer DeVecchio
- Alper Sen
- G. Thomas Budd (ORCID: https://orcid.org/0000-0002-1128-6185)
- Joseph Foss (ORCID: https://orcid.org/0000-0002-4050-7151)
- Emily E. Rhoades
- Jacob Steenblik
- N. Lynn Henry (ORCID: https://orcid.org/0000-0002-4771-5930)
- Daniel Miller Rotroff (ORCID: https://orcid.org/0000-0003-0553-3220)
- Bihua Bie (ORCID: https://orcid.org/0000-0002-5497-2257)
- Ken B. Johnson (ORCID: https://orcid.org/0000-0003-2004-314X)
- Mei Wei
- Carla Bou Dargham
Institutions
- Cleveland Clinic (US)
- University of Arizona (US)
- University of Utah (US)
- University of Michigan (US)
- Huntsman Cancer Institute (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12885-025-14901-7
- Citations
- 1
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.05