Lactylation-induced ALKBH5 targets RNF123 to worsen retinal Müller cell activation through PKM2-regulated Glycolysis in diabetic retinopathy
Lactate increases glycolysis through the ALKBH5-RNF123-PKM2 signaling axis to form a feedback regulation mechanism to activate Müller cells, which is an important pathological mechanism of DR.
Authors
- Yifan Hu (ORCID: https://orcid.org/0009-0003-7354-6944)
- Ye Sun (ORCID: https://orcid.org/0000-0002-3464-4600)
- Yujia Xu
- Shasha Luo (ORCID: https://orcid.org/0009-0008-7519-9647)
Institutions
- Jiangnan University (CN)
- Wuxi No.2 People's Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12967-025-07129-3
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Wuxi Municipal Bureau on Science and Technology