A Case Series on Extranodal Non-Hodgkin’s Lymphoma

Introduction: Non-Hodgkin’s lymphoma is broadly classified into B- and T-cell lymphomas. Accurate diagnosis and classification are essential for the appropriate management and prognostication of lymphomas. Aim and Objectives: To analyse the histopathological spectrum of extra nodal Non-Hodgkin’s lymphomas encountered in the series and to evaluate the utility of immunohistochemistry in the classification of extra nodal Non-Hodgkin’s lymphomas. Methodology: This is a descriptive study which includes seven cases of extranodal lymphomas that were reported in the Department of Pathology, Coimbatore Medical College, Coimbatore, over a period of one year, from March 2024 to March 2025 and reviewed in this study. Results and Discussion: Seven cases included in this study were from seven different sites, like Eyelid, Central Nervous System, Scalp, Spleen, Thyroid, Anal canal and Parapharyngeal wall. The most common type of extra nodal non–Hodgkin’s lymphoma in this study was Diffuse Large B-Cell Lymphoma (3 cases), constituting 43%, followed by Plasmablastic Lymphoma (2 cases), constituting 29% and Anaplastic large cell lymphoma (1 case) and Marginal Zone Lymphoma (1 case), each constituting 14%. Conclusion: Most of the extra nodal Non-Hodgkin lymphomas confer a worse prognosis than their nodal counterpart. So early diagnosis and treatment are essential. Histopathological diagnosis plays a vital role in identifying these tumours in rare sites.