Effects of different reperfusion durations on neuronal mitochondrial ultrastructure following cerebral ischemia in diabetic rats: a transmission electron microscopy study

(1) A diabetic cerebral I/R injury model was successfully established using STZ combined with bilateral carotid artery occlusion and hypotension. (2) Diabetes markedly exacerbates and prolongs mitochondrial damage following cerebral I/R. Impaired recovery of mitochondrial ultrastructure represents a critical determinant of stroke prognosis in diabetic patients, providing a well-defined therapeutic target for subsequent fundamental research and intervention strategies.