Bactericidal activity and Inhibition of levofloxacin-induced resistance by antibacterial combination against hypervirulent Klebsiella pneumoniae
These results demonstrated that levofloxacin combined with amikacin or ceftazidime exhibited superior bactericidal activities compared to levofloxacin against hvKP and might prevent levofloxacin-induced resistance related to oqxAB overexpression.
Authors
- Qingqing Xu (ORCID: https://orcid.org/0000-0002-7703-5872)
- Minggui Wang (ORCID: https://orcid.org/0000-0001-7682-5859)
- Xiaogang Xu (ORCID: https://orcid.org/0000-0003-1537-0250)
- Xiaoyu Zhao (ORCID: https://orcid.org/0000-0002-1394-7194)
- Jinshan Suo (ORCID: https://orcid.org/0000-0001-9857-6806)
- Dan Li (ORCID: https://orcid.org/0000-0002-0922-9528)
- Yi Li (ORCID: https://orcid.org/0000-0002-5849-6040)
- Ding Li (ORCID: https://orcid.org/0000-0003-3130-6099)
- Alimire Aimaiti
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12941-025-00826-3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Daiichi Sankyo Europe