A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure
We report a new cluster of variants on chromosome 12q15, overlapping the YEATS4 gene, strongly associated with the resister phenotype in two populations of PWH. Our results contribute to the understanding of the molecular mechanisms that block transmission of Mtb.
Authors
- James Bean (ORCID: https://orcid.org/0000-0001-6733-5794)
- Jérémy Manry (ORCID: https://orcid.org/0000-0001-5998-2051)
- Maxime Rotival (ORCID: https://orcid.org/0000-0003-2519-8044)
- Hanaa Skhoun (ORCID: https://orcid.org/0000-0002-4081-1604)
- Elouise E. Kroon (ORCID: https://orcid.org/0000-0002-8551-3301)
- Robert John Wilkinson (ORCID: https://orcid.org/0000-0002-2753-1800)
- Vinicius M. Fava (ORCID: https://orcid.org/0000-0001-9142-1713)
- Yoann Seeleuthner (ORCID: https://orcid.org/0009-0000-2670-6026)
- Daniel W. Fitzgerald (ORCID: https://orcid.org/0000-0003-1765-0598)
- Matthieu Chaldebas (ORCID: https://orcid.org/0000-0002-4920-3947)
- Erwin Schurr (ORCID: https://orcid.org/0000-0002-2640-536X)
- Gaspard Kerner (ORCID: https://orcid.org/0000-0003-0146-9428)
- Aniss Rafik
- Ahmed Aziz Bousfiha (ORCID: https://orcid.org/0000-0002-5011-9873)
- Kathleen F. Walsh (ORCID: https://orcid.org/0000-0002-9001-3918)
- Jamila El Baghdadi (ORCID: https://orcid.org/0000-0002-1920-2310)
- Astrid Marchal (ORCID: https://orcid.org/0000-0003-0648-8126)
- Jonathan Bohlen (ORCID: https://orcid.org/0000-0003-0458-9484)
- Eileen G. Hoal (ORCID: https://orcid.org/0000-0002-6444-5688)
- Stéphanie Boisson‐Dupuis (ORCID: https://orcid.org/0000-0002-7115-116X)
- Clément Conil
- Monica Dallmann-Sauer
- Marlo Möller (ORCID: https://orcid.org/0000-0002-0805-6741)
- Haralambos Mourelatos
- Marc Antoine Jean‐Juste
- Peng Zhang (ORCID: https://orcid.org/0000-0002-6129-567X)
- A. Abid (ORCID: https://orcid.org/0000-0003-4885-6572)
- Hanane El Ouazzani
- Aurélie Cobat
- Laurent Abel
- Jean-Laurent Casanova (ORCID: https://orcid.org/0000-0002-7782-4169)
- Jean W. Pape
Institutions
- South African Medical Research Council (ZA)
- Centre National de la Recherche Scientifique (FR)
- Memorial Sloan Kettering Cancer Center (US)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Inserm (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Cornell University (US)
- Stellenbosch University (ZA)
- The Francis Crick Institute (GB)
- Military Hospital (PK)
- McGill University Health Centre (CA)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- National Institute for Theoretical Physics (ZA)
- CEA Paris-Saclay (FR)
- Center for Global Health (US)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
- Centre Hospitalier Universitaire Ibn Rochd (MA)
- Gheskio Centers (HT)
- Institut des Maladies Génétiques Imagine (FR)
- Hôpital Militaire Moulay Ismail (MA)
- Imperial College London (GB)
- McGill University (CA)
- Ludwig-Maximilians-Universität München (DE)
- Rockefeller University (US)
- University of Hassan II Casablanca (MA)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s13073-025-01547-0
- Citations
- 2
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Institutes of Health