Molecular cargo of small EVs from NSCLC patient BALF and plasma: unveiling their role in airway inflammation and immune regulation in a novel human 3D bronchial model

This study provides the first functional evidence that NSCLC-derived EVs drive immune suppression and tumor-supportive changes in a human 3D airway model, closely mimicking in vivo lung conditions. The identification of EGFR suppression as a driver of macrophage polarization underscores the need to consider macrophage-specific EGFR regulation in anti-EGFR therapies to prevent unintended protumorigenic effects. These findings pave the way for future studies exploring EV cargo, such as miRNAs, as potential therapeutic targets in NSCLC.

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Publication Details

Journal
Cell Communication and Signaling
Published
2025-10-15
DOI
https://doi.org/10.1186/s12964-025-02423-5
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
0.00

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article

Molecular cargo of small EVs from NSCLC patient BALF and plasma: unveiling their role in airway inflammation and immune regulation in a novel human 3D bronchial model

Łukasz Zaręba, Karolina Soroczyńska, Malgorzata Czystowska, Zuzanna Homoncik et al.
Cell Communication and Signaling
Nanoplatforms for cancer theranostics
article

Molecular cargo of small EVs from NSCLC patient BALF and plasma: unveiling their role in airway inflammation and immune regulation in a novel human 3D bronchial model

Łukasz Zaręba, Karolina Soroczyńska, Malgorzata Czystowska, Zuzanna Homoncik, Joanna Domagała‐Kulawik, Magdalena Długołęcka, Małgorzata Polubiec-Kownacka, Diana Wierzbicka, Jacek Szymański, Kannathasan Thetchinamoorthy, Ewa Frankiewicz
article en

Abstract

This study provides the first functional evidence that NSCLC-derived EVs drive immune suppression and tumor-supportive changes in a human 3D airway model, closely mimicking in vivo lung conditions. The identification of EGFR suppression as a driver of macrophage polarization underscores the need to consider macrophage-specific EGFR regulation in anti-EGFR therapies to prevent unintended protumorigenic effects. These findings pave the way for future studies exploring EV cargo, such as miRNAs, as potential therapeutic targets in NSCLC.

Cell Communication and SignalingVol. 23(1)
Maria Curie-Skłodowska University (PL), Medical University of Warsaw (PL), International Institute of Molecular and Cell Biology (PL), The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Narodowa Agencja Wymiany Akademickiej, Wojskowy Instytut Medyczny, Robert Koch Institut
Openalex Percentile: Top 72%
Nanoplatforms for cancer theranostics
DOIOpen Access PDFOpenAlex
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Molecular cargo of small EVs from NSCLC patient BALF and plasma: unveiling their role in airway inflammation and immune regulation in a novel human 3D bronchial model — Łukasz Zaręba, Karolina Soroczyńska, et al. · Cell Communication and Signaling (2025) | TGRS Research Map | TGRS