Dexmedetomidine pretreatment improves postsurgical delay in neurocognitive recovery in aged mice by inhibiting hippocampal microglial activation via activation of cholinergic anti-inflammatory pathways
DEX pretreatment ameliorated DNR in aged mice is related to inhibition of microglial activation, which was at least partially attributed to activation of the cholinergic anti-inflammatory pathway.
Authors
- Guicheng Wang (ORCID: https://orcid.org/0009-0001-0257-8944)
- Jing Zhao (ORCID: https://orcid.org/0000-0001-7346-9959)
- Jiang‐Nan Wu (ORCID: https://orcid.org/0000-0003-4378-2391)
- Chengxiao Liu (ORCID: https://orcid.org/0000-0002-9067-533X)
- Gongming Wang (ORCID: https://orcid.org/0000-0003-0453-4002)
- Shiyu Hao (ORCID: https://orcid.org/0009-0001-8201-2632)
- Jingjing Li (ORCID: https://orcid.org/0000-0001-9638-7964)
- Xiaowei Li (ORCID: https://orcid.org/0000-0003-3978-3420)
- Xu Wang (ORCID: https://orcid.org/0000-0003-0593-8615)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-9184-0587)
- Qidi Zhang (ORCID: https://orcid.org/0000-0002-6823-6015)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jinan Central Hospital (CN)
- Shandong Provincial Hospital (CN)
- Taian City Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12868-025-00969-1
- Citations
- 1
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China