Efficacy of artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria among children aged 2–11 years in the Asante Akim North Municipality, Ghana: a single-arm open trial
The study confirmed that artesunate (AS) combined with amodiaquine (AQ) remains an effective treatment for uncomplicated Plasmodium falciparum malaria in children aged 2-11 years in Ghana. Additionally, a high prevalence of a haplotype associated with reinfection following artemether-lumefantrine treatment, one of Ghana's first-line antimalarial therapies, was observed.
Authors
- Henry Hanson (ORCID: https://orcid.org/0000-0001-8256-4683)
- John Amuasi (ORCID: https://orcid.org/0000-0002-8640-2662)
- Oumou Maïga Ascofaré
- Nimako Sarpong
- Geoffrey Foli
- Kwadwo Sarfo Marfo
- Anna Jaeger (ORCID: https://orcid.org/0000-0001-8833-0618)
- Nana Safi Almoustapha
- Jürgen May (ORCID: https://orcid.org/0000-0001-7831-8420)
- James Osei-Mensa (ORCID: https://orcid.org/0000-0002-8978-6550)
- Esther Placca
- A. Gyimah
- Morrah Oppong
- Diana Nunana Tsali
- Alfred Martey
Institutions
- Kwame Nkrumah University of Science and Technology (GH)
- German Center for Infection Research (DE)
- Kumasi Centre for Collaborative Research in Tropical Medicine (GH)
- Garden City University College (GH)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12936-025-05490-8
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European and Developing Countries Clinical Trials Partnership