Pro-Apoptotic and Cytotoxic Effects of Melittin on HL-60 Acute Promyelocytic Leukemia Cells: Implications for Retinoid-Independent Therapy
These findings confirm and extend established evidence by demonstrating that melittin's mitochondrial apoptotic mechanism is consistently active in promyelocytic HL-60 model (PML/RARα-negative). This retinoid-independent mechanism suggests potential therapeutic utility for ATRA-resistant cases or as a complementary strategy in APL treatment. However, selectivity validation in non-cancerous hematopoietic cells represents an important future research priority.
Authors
- Maksymilian Stela (ORCID: https://orcid.org/0000-0002-7471-4175)
- Michał Bijak (ORCID: https://orcid.org/0000-0002-7838-4097)
- Marcin Podogrocki (ORCID: https://orcid.org/0000-0001-7566-4205)
- Tomasz Popławski (ORCID: https://orcid.org/0000-0003-2300-7339)
- Michał Ceremuga (ORCID: https://orcid.org/0000-0001-6851-9536)
- Natalia Cichoń (ORCID: https://orcid.org/0000-0002-0139-2451)
- Leslaw Gorniak (ORCID: https://orcid.org/0000-0001-9873-9521)
Institutions
- University of Łódź (PL)
- Wojskowy Instytut Techniki Pancernej i Samochodowej (PL)
- Medical University of Lodz (PL)
Publication Details
- Journal
- Molecules
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3390/molecules30204093
- Citations
- 1
- Primary Topic
- Healthcare and Venom Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39