Cp*Co(III)-Catalyzed <i>ortho</i> -C–H Alkynylation of Pivalanilides with Bromoalkynes
A straightforward and efficient Cp*Co(III)-catalyzed <i>ortho</i>-C-H alkynylation of anilides with diverse readily available bromoalkynes was developed in which the weakly coordinating amide carbonyl group served as the directing group. This strategy provides a practical route for the synthesis of <i>ortho</i>-alkynylanilines, featuring good functional group tolerance and a broad substrate scope. Aryl-, alkyl-, and silyl-substituted bromoalkynes are compatible substrates in this catalytic system. Furthermore, subsequent synthetic transformations of the products demonstrate the synthetic utility of this methodology.
Authors
- Rui Huang (ORCID: https://orcid.org/0000-0001-5952-2936)
- Yanqi Li (ORCID: https://orcid.org/0000-0002-1437-9301)
- Heyun Sheng (ORCID: https://orcid.org/0009-0005-4614-9745)
- Jiajia Yu (ORCID: https://orcid.org/0000-0002-2677-1933)
- Yongqi Yu (ORCID: https://orcid.org/0000-0001-6086-7851)
- Ting Li (ORCID: https://orcid.org/0000-0002-2186-6992)
- Wenguang Li (ORCID: https://orcid.org/0009-0003-4969-4621)
- Mengdan You
Institutions
- Anyang Academy of Agricultural Sciences (CN)
- Nanyang Normal University (CN)
- Nanyang Institute of Technology (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1021/acs.joc.5c02098
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94