Progressive Loss of Muscle Strength: The Effects of Ageing and Sarcopenia on Muscle Function in Older Females

<b>Background/Objectives</b>: Sarcopenia is the progressive loss of muscle mass, strength, and/or function, leading to reduced physical performance, independence, and social participation. This study aimed to analyze the effects of age-related muscle strength loss and sarcopenia on muscle function during standing in older females. <b>Methods</b>: This study included experimental and modeling analyses using the AnyBody Modeling System in 20 older females. Based on DEXA results, participants were divided into older females without sarcopenia (OF) and with sarcopenia (OFS). Body posture while standing was assessed using the Zebris APGMS Pointer system. A model of muscular strength changes due to natural aging and progressive sarcopenia was developed based on literature data. The experimental results informed model studies in the AnyBody Modeling System, which incorporated changes in body posture and loss of muscle strength. <b>Results</b>: Total muscle activity during standing increases with age; however, this increase is significantly more pronounced in individuals with sarcopenia, especially after the age of 65. At 65, total muscle activity was 15% higher in the OFS model than in the OF model, while the difference was 44% at 80. After age 65, muscle fatigue increased considerably with progressive sarcopenia. At age 80, muscle fatigue while standing with sarcopenia can be more than three times higher than in those without sarcopenia. <b>Conclusions</b>: Aging leads to increased muscle activity while standing, and sarcopenia further amplifies this effect, particularly in individuals over 65. Modeling results highlight the pronounced impact of sarcopenia on muscle fatigue, demonstrating its significant functional consequences in older females.