Distinct Defects in Marginal Zone B Cells and Filtration Function Characterize Hyposplenism in Persons With HIV-1 on Prolonged ART
These findings highlight that PWH exhibit depletion of splenic marginal zone B cells, and some demonstrate splenic filtration dysfunction, reflecting persistent splenic impairment despite extended viral suppression. Further research is needed to understand the long-term impact of HIV on splenic function and to develop strategies to improve clinical outcomes in this aging population.
Authors
- Anne‐Sophie Bedin (ORCID: https://orcid.org/0000-0001-6041-393X)
- Amandine Pisoni (ORCID: https://orcid.org/0000-0001-5426-3998)
- Édouard Tuaillon (ORCID: https://orcid.org/0000-0001-5866-9530)
- Nathalie Pansu (ORCID: https://orcid.org/0000-0002-3702-4589)
- Matthéo Alcaraz (ORCID: https://orcid.org/0000-0001-5308-9043)
- Ségolène Debiesse
- Alain Makinson (ORCID: https://orcid.org/0000-0003-2817-8444)
- Corinne Merle De Boever
- Joseph Fouchet
Institutions
- Inserm (FR)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Établissement Français du Sang (FR)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-10-11
- DOI
- https://doi.org/10.1093/ofid/ofaf644
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00