Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression
We identified DNA methylation signals from multiple tissue types in ALS cfDNA, highlighting diverse tissue involvement in ALS pathology. These findings promote epigenetic cfDNA analysis as a powerful tool for advancing our understanding of neurodegenerative disease.
Authors
- M. J. Thompson (ORCID: https://orcid.org/0000-0002-9954-1629)
- Christa Caggiano (ORCID: https://orcid.org/0000-0001-5755-1274)
- Anjali K. Henders (ORCID: https://orcid.org/0000-0003-3672-1451)
- Matteo Pellegrini (ORCID: https://orcid.org/0000-0001-9355-9564)
- Fleur C. Garton (ORCID: https://orcid.org/0000-0002-1490-5930)
- Xiaoyu Qian (ORCID: https://orcid.org/0000-0001-6954-1022)
- Shyuan Thieu Ngo (ORCID: https://orcid.org/0000-0002-1388-2108)
- Susan Heggie
- Allan F. McRae (ORCID: https://orcid.org/0000-0001-5286-5485)
- Barbara Celona (ORCID: https://orcid.org/0000-0001-5391-8155)
- Marco Morselli (ORCID: https://orcid.org/0000-0003-3351-5791)
- Frederik J. Steyn (ORCID: https://orcid.org/0000-0002-4782-3608)
- Robert D. Henderson (ORCID: https://orcid.org/0000-0002-2820-8183)
- Peter J. Nestor (ORCID: https://orcid.org/0000-0002-5860-5921)
- Pamela McCombe (ORCID: https://orcid.org/0000-0003-2704-8517)
- Shivangi Wani (ORCID: https://orcid.org/0000-0002-9697-6432)
- Noah Zaitlen (ORCID: https://orcid.org/0000-0002-3553-3670)
- Leanne M. Wallace (ORCID: https://orcid.org/0000-0003-4310-7572)
- Naomi R. Wray (ORCID: https://orcid.org/0000-0001-7421-3357)
- Anela Tosevska (ORCID: https://orcid.org/0000-0002-0892-7068)
- Gregory G. Heuer (ORCID: https://orcid.org/0000-0002-1989-0141)
- Kodi Taraszka (ORCID: https://orcid.org/0000-0002-1921-2113)
- Kathryn Thorpe
- Gwendolyn English (ORCID: https://orcid.org/0000-0002-3417-3511)
- Caitlin McElligott
- Catherine Lomen-Hoerth
Institutions
- University of Parma (IT)
- University of California, Los Angeles (US)
- The University of Queensland (AU)
- University of California, San Francisco (US)
- Royal Brisbane and Women's Hospital (AU)
- UCLA Health (US)
- UCLA Medical Center (US)
- Dana-Farber Cancer Institute (US)
- Centre for Genomic Regulation (ES)
- Mater Adult Hospital (AU)
- Medical University of Vienna (AT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s13073-025-01542-5
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Motor Neurone Disease Research Institute of Australia
- University of California, San Francisco
- Medical Research Council
- National Health and Medical Research Council