5-Iodotubercidin: a novel anti-tuberculosis lead with promising antimicrobial activity, pharmacokinetics, and safety profile
Despite its moderate toxicity, the promising anti-TB activity and favorable PK profile of 5-ITu support its potential as a lead compound for structural optimization in anti-TB drug development.
Authors
- Qiyue Jia
- Mengxin Xu (ORCID: https://orcid.org/0000-0002-3826-7371)
- Bin Wang (ORCID: https://orcid.org/0000-0001-7104-4543)
- E. -L. Liu
- Zimo Wang (ORCID: https://orcid.org/0009-0007-3137-5621)
- Lu Wang (ORCID: https://orcid.org/0000-0003-2617-655X)
- Xuelin Wang (ORCID: https://orcid.org/0000-0002-9229-0804)
- Yun Ye (ORCID: https://orcid.org/0000-0002-3346-4640)
- Yu Lu
Institutions
- Capital Medical University (CN)
- Beijing Chest Hospital (CN)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1093/jambio/lxaf257
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00