Future myocardial infarction after an acute coronary syndrome and pharmacogenetic response to dalcetrapib
Despite guideline directed therapy following ACS, history of prior coronary events and on-treatment LDL-C, A1c, hs-CRP and blood pressure remain determinants of future MI. In the Dal-GenE AA genotype patients, dalcetrapib reduced the rate of MI, independently of those variables. The Dal-GenE 2 trial is designed to confirm this pharmacogenetic hypothesis.
Authors
- Fouzia Laghrissi‐Thode (ORCID: https://orcid.org/0000-0001-7232-3077)
- David D. Waters (ORCID: https://orcid.org/0000-0002-2786-8198)
- Marie‐Claude Guertin (ORCID: https://orcid.org/0000-0001-8523-5148)
- Marie‐Pierre Dubé (ORCID: https://orcid.org/0000-0001-8442-4393)
- John J.V. McMurray (ORCID: https://orcid.org/0000-0002-6317-3975)
- Wolfgang Köenig (ORCID: https://orcid.org/0000-0002-2064-9603)
- Simon Kouz (ORCID: https://orcid.org/0000-0003-0860-4135)
- Jean‐Claude Tardif (ORCID: https://orcid.org/0000-0002-8200-8983)
- Annik Fortier (ORCID: https://orcid.org/0000-0002-8534-2354)
- Therèse Heinonen
- Harvey D. White (ORCID: https://orcid.org/0000-0001-7712-6750)
- Valtteri Muroke (ORCID: https://orcid.org/0000-0003-0972-3873)
- David Kallend (ORCID: https://orcid.org/0000-0003-3680-285X)
- Aldo P. Maggioni (ORCID: https://orcid.org/0000-0003-2764-6779)
- J. Wouter Jukema
- Marc A. Pfeffer
Institutions
- Brigham and Women's Hospital (US)
- San Francisco General Hospital (US)
- University of Auckland (NZ)
- Bell (Canada) (CA)
- Universität Ulm (DE)
- Serco (United Kingdom) (GB)
- Leiden University Medical Center (NL)
- Montreal Heart Institute (CA)
- Auckland City Hospital (NZ)
- Cegep regional de Lanaudiere (CA)
- British Heart Foundation (GB)
- Associazione Nazionale Medici Cardiologi Ospedalieri (IT)
- Netherlands Heart Institute (NL)
- Florence (Netherlands) (NL)
- Zimmer Biomet (United States) (US)
- German Centre for Cardiovascular Research (DE)
- Dürr Systems (Czechia) (CZ)
- Deutsches Herzzentrum München (DE)
- Université de Montréal (CA)
- University of Glasgow (GB)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1093/eurjpc/zwaf661
- Citations
- 1
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81