Euploid but failing to implant? Insights from trophectoderm transcriptomics of euploid blastocysts using an in vitro model
The study demonstrates that mural TE gene expression differs significantly between euploid blastocysts that attach and those that do not, highlighting molecular pathways potentially linked to implantation success. Despite human implantation typically occurring through the polar TE, mural TE transcriptomic profiles may provide predictive value for embryo selection and deepen our understanding of early implantation biology. Further validation through proteomic studies and larger cohorts is needed to confirm these candidate biomarkers.
Authors
- Mireia Boluda-Navarro
- María Luisa Pardiñas (ORCID: https://orcid.org/0000-0002-6381-2888)
- María José de los Santos (ORCID: https://orcid.org/0000-0003-1394-8661)
- Amparo Mercader (ORCID: https://orcid.org/0000-0002-5476-3703)
- Ángel Martín (ORCID: https://orcid.org/0000-0003-3026-9214)
- David Ortega-Jaén (ORCID: https://orcid.org/0009-0008-6837-9308)
- Antonio Capalbo (ORCID: https://orcid.org/0000-0003-0109-323X)
- Carlos Mora‐Martínez (ORCID: https://orcid.org/0000-0002-0542-2654)
- Julia Gil (ORCID: https://orcid.org/0009-0004-9830-3153)
Institutions
- University of Chieti-Pescara (IT)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Valencian Infertility Institute (ES)
- Instituto Valenciano de la Edificación (ES)
Publication Details
- Journal
- F&S Science
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.xfss.2025.09.003
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00