A severe case of periorbital necrotising fasciitis and successful management using Pelnac dermal substitute

PurposePeriorbital necrotizing fasciitis (PNF) is a rare but potentially life-threatening condition requiring prompt intervention to balance tissue debridement and functional preservation.Case ReportWe present a 63-year-old female with bilateral PNF, rapid progression and cervical extension, requiring multiple debridements. Once the acute infective process was controlled, a dermal substitute was used in lieu of any local skin flaps or grafts in the upper eyelids, facilitating dermal regeneration. Despite extensive loss of adnexal tissue, the use of dermal substrate in the early reconstructive phase provided adequate ocular protection and allowed sufficient restoration of tissue to avoid any further surgery in the upper eyelids and to permit a modest lower eyelid repair.ConclusionsThis case highlights PNF's challenging management, requiring rapid intervention, novel reconstructive materials, and tailored surgical strategies. It underscores the potential for favourable outcomes even in severe cases through multidisciplinary care and early use of bioengineered dermal scaffolds.

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Publication Details

Journal
European Journal of Ophthalmology
Published
2025-10-15
DOI
https://doi.org/10.1177/11206721251386092
Primary Topic
Streptococcal Infections and Treatments
Type
article
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article

A severe case of periorbital necrotising fasciitis and successful management using Pelnac dermal substitute

Harry Rosen, C. Schulz, Sarith Makuloluwe, N Mackenzie et al.
European Journal of Ophthalmology
Streptococcal Infections and Treatments
article

A severe case of periorbital necrotising fasciitis and successful management using Pelnac dermal substitute

Harry Rosen, C. Schulz, Sarith Makuloluwe, N Mackenzie, Aoife Naughton, H. Courtenay Clarke
article en

Abstract

PurposePeriorbital necrotizing fasciitis (PNF) is a rare but potentially life-threatening condition requiring prompt intervention to balance tissue debridement and functional preservation.Case ReportWe present a 63-year-old female with bilateral PNF, rapid progression and cervical extension, requiring multiple debridements. Once the acute infective process was controlled, a dermal substitute was used in lieu of any local skin flaps or grafts in the upper eyelids, facilitating dermal regeneration. Despite extensive loss of adnexal tissue, the use of dermal substrate in the early reconstructive phase provided adequate ocular protection and allowed sufficient restoration of tissue to avoid any further surgery in the upper eyelids and to permit a modest lower eyelid repair.ConclusionsThis case highlights PNF's challenging management, requiring rapid intervention, novel reconstructive materials, and tailored surgical strategies. It underscores the potential for favourable outcomes even in severe cases through multidisciplinary care and early use of bioengineered dermal scaffolds.

European Journal of OphthalmologyVol. 36(2)
Queen Alexandra Hospital (GB)
Openalex Percentile: Top 61%
Streptococcal Infections and Treatments
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A severe case of periorbital necrotising fasciitis and successful management using Pelnac dermal substitute — Harry Rosen, C. Schulz, et al. · European Journal of Ophthalmology (2025) | TGRS Research Map | TGRS